One thing to notice is that the default case matters a lot. This asymmetry is because you switch decisions in different possible worlds - when you would take Adderall but stop you’re in the world where Adderall doesn’t work, and when you wouldn’t take Adderall but do you’re in the world where Adderall does work (in the perfect information case, at least). One of the ways you can visualize this is that you don’t penalize tests for giving you true negative information, and you reward them for giving you true positive information. (This might be worth a post by itself, and is very Litany of Gendlin.)
Sun: This is a day I devote to spiritual disciplines and deep personal exploration, along with a hefty dose of neurogenesis, and for a day such as this, I’ll use a more potent neuron sprouting and ego-dissolving mix – most notably a blend of psilocybin microdose with Lion’s Mane extract and niacin (if the skin flush and increased blood flow from niacin tends to be too much for you, you can also use “nicotinamide riboside”, a form of vitamin B3 that has similar effects without the flushing).
Take at 11 AM; distractions ensue and the Christmas tree-cutting also takes up much of the day. By 7 PM, I am exhausted and in a bad mood. While I don’t expect day-time modafinil to buoy me up, I do expect it to at least buffer me against being tired, and so I conclude placebo this time, and with more confidence than yesterday (65%). I check before bed, and it was placebo.
Fish oil (Examine.com, buyer’s guide) provides benefits relating to general mood (eg. inflammation & anxiety; see later on anxiety) and anti-schizophrenia; it is one of the better supplements one can take. (The known risks are a higher rate of prostate cancer and internal bleeding, but are outweighed by the cardiac benefits - assuming those benefits exist, anyway, which may not be true.) The benefits of omega acids are well-researched.

I’ve tried a few different ways of taking my nootropics—in the morning, in the afternoon, in addition to coffee, as a replacement for coffee—and so far, the effects I'm feeling are much more subtle than I expected. There’s no sweaty-palmed intensity, no eight-hour uninterruptible work sprints, and none of the hyperactivity you’d associate with a caffeine high. It’s just a sensation of being a little amped up, and of being slightly less distracted than normal.


The main concern with pharmaceutical drugs is adverse effects, which also apply to nootropics with undefined effects. Long-term safety evidence is typically unavailable for nootropics.[13] Racetams — piracetam and other compounds that are structurally related to piracetam — have few serious adverse effects and low toxicity, but there is little evidence that they enhance cognition in people having no cognitive impairments.[19]
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